Magnesium is needed to activate countless enzymes, and a deficiency leads to inefficient and blocked energy production. A further problem is that excess calcium damages the cell membrane and makes it difficult for nutrients to move in and wastes to move out.
When the intracellular calcium level gets too high, the cell will die. Here we can see the importance of boron as a regulator of cell membrane functions, especially in regard to movements of calcium and magnesium. With boron deficiency, too much calcium moves into the cell while magnesium cannot move inside to displace it. This is the condition of old age and of the boron-deficiency diseases leading up to it.
While in good health and especially in younger years, a calcium - magnesium ratio of 2 : 1 is normal and beneficial and supplied with a good diet.
But with increasing age, boron deficiency and resulting disease conditions, we need progressively less calcium and more magnesium. For boron to be fully effective in reversing tissue calcification, ample magnesium is required. For elderly individuals, I recommend to mg of magnesium together with the daily borax supplementation spaced out during the day , and with protracted joint problems additional trans-dermal magnesium. However, oral magnesium may need to be adjusted according to its laxative effect.
I am doubtful whether calcium supplements are needed and beneficial , even in case of osteoporosis. In my view, these individuals have plenty of calcium stored in soft tissues where it does not belong, and supplementing boron and magnesium is expected to redeposit this misplaced calcium into bones. I regard the medical focus on a high calcium intake as a prescription for accelerated aging. In some countries e. There is no "food-grade" borax available or necessary. Boric acid, if available, may be used at about the dose of borax.
Firstly, dissolve a lightly rounded teaspoonful grams of borax in 1 liter of good quality water free of chlorine and fluoride. This is your concentrated solution. Keep the bottle out of reach of small children. This has 25 to 30 mg of borax and provides about 3 mg of boron. Take 1 dose per day mixed with drink or food. If that feels right then take a second dose with another meal. If there is no specific health problem or as a maintenance dose you may continue indefinitely with 1 or 2 doses daily.
If you do have a problem, such as arthritis, osteoporosis and related conditions, menopause, stiffness due to advancing years, and also to improve low sex hormone production, increase intake to 3 or more spaced-out standard doses for several months or longer until you feel that your problem has sufficiently improved.
Then drop back to 1 or 2 doses per day. If you want to try the higher doses recommended by Earth Clinic for treating Candida and removing fluoride from the body - using your bottle of concentrated solution - then use:. Always start with a standard dose and increase gradually to the intended maximum.
Take the maximum amounts for 4 or 5 days a week as long as required. Borax is rather alkaline and in higher concentrations has a soapy taste.
You may disguise this with lemon juice, vinegar or ascorbic acid. Keep the bottle with the concentrated solution out of reach of small children. Borax and boric acid have been classified as reproductive poisons in Europe, and since December are no longer available to the public within the EU. Presently, borax is still available in Switzerland 15 , but shipment to Germany is not permitted. In Germany, a small amount 20 - 50 grams may be ordered through a pharmacy as ant poison it will be registered.
Boron tablets can be bought from health shops or the Internet, commonly with 3 mg of boron. These contain tightly bound boron not present in ionic form as with borax or boric acid. While suitable as a general boron supplement, I do not expect them to work against Candida and mycoplasmas, or as a quick arthritis, osteoporosis or menopause cure. Most scientific studies and individual experiences were with borax or boric acid.
To improve effectiveness, I recommend 3 or more spaced-out boron tablets daily for an extended period combined with sufficient magnesium and a suitable antimicrobial program While side-effects from pharmaceutical drugs tend to be negative and often dangerous, with natural medicine, such as borax therapy, these are usually healing reactions with beneficial long-term effects.
Most common is the Herxheimer reaction from eliminating Candida. In some of the above forum posts, rapid improvement was experienced within days. This is always a functional response. High cellular calcium levels cause muscle contraction with cramps or spasms as a common cause of pain.
Boron , especially together with magnesium , can rapidly relax these muscles and take away the pain. However, with long-standing severe calcifications a large amount of calcium cannot be redistributed in a short time. This leads to increased calcium levels in the affected area, especially the hips and shoulders, and can cause problems for a considerable time, such as a tendency to severe cramping and pain, or problems with the blood circulation, or nerve transmission.
Nerve-related effects in hands and feet may be numbness, or reduced sensitivity or feeling in the skin. Higher amounts of calcium and fluoride passing through the kidneys may cause temporary kidney pain. Such healing reactions cannot be avoided when aiming for a higher level of health.
Whenever you experience an unpleasant effect reduce or temporarily stop borax intake until the problem subsides. Then gradually start increasing again. Helpful additional measures are a a greatly increased fluid intake, b using more organic acids such as lemon juice, ascorbic acid or vinegar, and c improving lymph flow as with rebounding, walking or inverted positions. Government health agencies are concerned about boron toxicity.
You might be concerned as well if you read the following, pertaining to sodium chloride or more commonly known as table salt 17 :. Chronic Effects on Humans: Mutagenic for mammalian somatic cells. Slightly hazardous in case of skin contact, ingestion or inhalation. Causes adverse reproductive effects in humans fetotoxicity, abortion by intraplacental route, may increase risk of Toxemia of Pregnancy in susceptible women.
May cause adverse reproductive effects and birth defects in animals, particularly rats and mice - fetotoxicity, abortion, musculoskeletal abnormalities, and maternal effects on ovaries, fallopian tubes. May affect genetic material mutagenic. Ingestion of large quantities can irritate the stomach with nausea and vomiting.
Continued exposure may produce dehydration, internal organ congestion, and coma. Studies with boric acid in the rat, mouse and rabbit, at high doses, demonstrate developmental effects on the fetus, including fetal weight loss and minor skeletal variations. The doses administered were many times in excess of those to which humans would normally be exposed.
No evidence of carcinogenicity in mice. No mutagenic activity was observed in a battery of short-term mutagenicity assays. Human epidemiological studies show no increase in pulmonary disease in occupational populations with chronic exposures to borate dust and no effect on fertility.
Table salt changes the genetic material and is mutagenic, while borax is harmless in this regard. Infants are most at risk from high borax ingestion. It has been estimated that 5 to 10 grams can cause severe vomiting, diarrhea, shock and even death, but it also says that lethal doses are not well documented in the literature.
Animal studies have identified reproductive toxicity as the most sensitive effects of boron ingestion. Most at risk is the developing fetus, and in the studied animals, rats were most affected. In one study, slight reductions in the fetal body weight were already found at The [has] no effect dose was set at less than With an added safety factor , a no effect value of 9. This dose corresponds to 17 grams of borax for 60 kg ingested for 3 generations! In another 3-generation study no problem was found at Human studies of the possible association between impaired fertility and high boron levels in water, soil and dust in a Turkish population, and boron mining and processing workers, found no effect.
One study even reported elevated fertility rates in borax production workers as compared to the U. All this is important because possible reproductive toxicity is the official reason for the present assault on borax. The sodium chloride MSDS mentioned above also states: "While sodium chloride has been used as a negative control in some reproductive studies, it has also been used as an example that almost any chemical can cause birth defects in experimental animals if studied under the right conditions.
Osteoporosis is responsible for more long-term hospital care than any other individual disease. This is due to the very high incidence of fractures, and especially the protracted nature of hip fractures.
This is a main source of income for the medical-pharmaceutical system. If the boron-magnesium cure for these diseases should become widely known, this vital income stream would dry up and the system collapse.
As this is the biggest and most profitable industry in the world, this cannot be allowed to happen. When Dr. Newnham discovered the boron-arthritis cure, it was not a big problem for the pharmaceuticals because news travelled slowly and was easily suppressed. This is very different now with Internet communication. Most research funding comes from the pharmaceutical industry, and nothing has come forward to duplicate Dr. Newnham's findings and other positive osteoporosis studies.
Instead, funding goes into the development of patentable boron drugs for limited application as in chemotherapy, or even to discredit boron. A test-tube experiment found that a relatively low dose of about 4 grams of borax can damage lymphocytes, just like an earlier test-tube study showed that vitamin C supplements are toxic. Most positive borax studies now come from China, Japan and Turkey.
Furthermore, PubMed is a publicly funded search facility for bio-medical research publications. While other articles for Newnham R. I suspect that they have been deliberately removed to prevent them from being quoted in other research. In addition, increasing effort goes into publicly demonizing borax for its alleged reproductive and infant toxicity.
As an example, I recently read an article by a 'senior scientist' of the supposedly 'green' Environmental Working Group. In it, the perceived dangers of borax were so exaggerated that most comments in effect said: "Thank you for opening my eyes. I did not know how poisonous and dangerous borax is, I certainly will not use it anymore in my laundry, or for cleaning my toilet and kitchen".
This is obviously a deliberate campaign to make people grateful for banning borax from public sale. The alkaline powder, also called sodium tetraborate or sodium borate, is a salt of boric acid. The mineral has been used for centuries as a flux for soldering. Research shows that today, about 75 percent of the world supply of borax is mined in Southern California, where it was discovered in the s.
You can easily find powered sodium borate for sale in home or department stores. In household products, sodium borate is used to remove stains mildew and mold. Perhaps the most well-known borax use is as a pesticide. Boric acid is manufactured from several borate minerals and brines, including borax.
Boric acid is made by combining sodium borate with a strong mineral acid, like hydrochloric acid. Plus, research suggests that the chemical is linked to endocrine disruption. Borax is commonly used in cleaning products because of its disinfecting and whitening effects. Beyond house cleaning, the mineral salt is used for many other purposes, including the following:. Sodium borate can be found in many cosmetic products, like body lotions, to shampoos and bath bombs.
But in the last few years, many articles have pointed out the potential toxic effects from this combination. Parents have been advised to use borax-free slime recipes instead. According to research published in Toxicology , fatal doses of borax for humans are estimated to be grams for children and grams for adults.
The most sensitive endpoints of borax toxicity is developmental and reproductive toxicity [ 2 ]. Borax causes irritation of skin and respiratory tract.
The gastrointestinal tract, skin, vascular system and brain are the principal organs and tissues affected. It causes nausea, persistant vomiting, abdominal pain, diarrhea, erythematous and exfoliative rash, unconsciousness, depression and renal failure. Brockman et al. Cattle consumed these chunks. They appeared depressed, were dehydrated and some had diarrhea. In the dead animals, the predominant lesion was hemorrhagic gastroenterititis [ 3 ]. Food additives are substances added to food to preserve flavor or improve its taste and appearance.
Food additives are one of the causes in many cancer types [ 4 ]. Carrageenan is one of the food additive that involve in cancer.
It is a naturally occurring gum derived from red seaweed. It is associated with loss of mammary myoepithelial cells in tissue culture provides a potential mechanism for increasing invasive mammary carcinoma [ 5 ] and induced colonic neoplasia in animal models [ 6 ]. Borax is used as a food additive in some countries with the E number E Although borax has reproductive toxicity, nephrotoxicity and neurotoxicity in human but the borax toxicity about human genetic materials and humoral immune cell still need to be investigated for food additive carcinogenesis.
The defect in genetic material and immune cell development involves in human carcinogenesis. In this study, we studied about the toxic effects of borax on immune cell proliferation lymphocyte proliferation and genotoxicity sister chromatid exchange. MTT [3- 4,5-dimethylthiazolyl -2,5-diphenyl-2H tetrazolium bromide] colorimetric assay is a standard colorimetric assay for measuring cellular growth.
It has been developed by Mosmann. It can also be used to determine cytotoxicity of toxic materials. Yellow MTT is reduced to purple formazan in the mitochondria of living cells. A solubilization solution is added to dissolve the insoluble purple formazan product into a colored solution. The absorbance of this colored solution can be quantified by measuring at a certain wavelength usually between and nm.
The absorption maximum is dependent on the solvent employed. This reduction takes place only when mitochondrial reductase enzymes are active, and therefore conversion can be directly related to the number of living cells. When the amount of purple formazan produced by cells treated with an agent is compared with the amount of formazan produced by untreated control cells, the effectiveness of the agent in causing death of cells can be deduced, through the production of a dose-response curve [ 7 ].
Various technical modifications for the MTT assay on different cell lines have done in many experiments about cancer. The MTT assay can be used for the chemosensitivity testing of short-term cell lines derived from human brain tumors [ 8 ]. Sister chromatid exchange SCEs represent the interchange of DNA replication products at apparently homologous chromosomal loci. These exchanges involve DNA breakage and reunion. This technic is used as a sensitive means of monitoring DNA damage.
It is useful for assessing the cytogenic impact of clastogenic agents on chromosomes. It can be performed in cultured cells in vitro or on cells from intact animals given BrdU in vivo. The increased resolution of SCE detection afforded by fluorescence or Giemsa technic has permitted localization of SCEs relative to chromosome-banding patterns.
In human chromosomes, SCEs occur preferentially in Q-negative bands or at the junction of Q-positive and Q-negative regions [ 10 ]. The toxic effects of borax to immune cell proliferation and genotoxicity in human were studied in vitro to verify borax toxicity. Heparinized blood from 40 consenting healthy male were collected.
The participants were given consent to donate blood for study in the borax toxicity research. This study was approved by Thammasat University ethic committee.
Phytohemagglutinin was added in RPMI medium as the mitogen and incubated for 72 hours. These doses were high as compared to being used as food additive but it is likely that due to high consumption it may be accumulative.
Forty lymphocyte cultures from forty blood samples were tested in each borax concentration. After 24 hours incubation, various concentrations of borax added to the wells to get the final concentration of 0.
The cells were incubated for an additional 24 hours. After 24 hours, 0. The medium was removed and formazan was dissolved in DMSO and the optical density was measured at nm. MTT assay of forty lymphocyte cultures in each borax concentration was carried out in duplicate fashion. Mean absorbance was calculate for the control wells and for each borax concentration in the test wells.
The degree of immune cell proliferation lymphocyte proliferation sensitivity to borax toxicity was based on the cytotoxicity index CI. Phytohemagglutinin was added in RPMI medium as the mitogen.
The borax solutions, 0. Forty lymphocyte cultures from forty samples were tested in each borax concentration. After 72 hours incubation, colcemid solution was added 30 minutes prior to the harvest. Metaphase cells were harvested by centrifugation, treated with 0. Slides were prepared and stained by the fluorescence plus Giemsa technic [ 12 ].
SCEs from forty lymphocyte cultures in each borax concentration were detected. SCEs were observed under microscope and scored in forty five metaphases per sample [ 13 ]. Statistical analysis for study the toxicity of each borax concentration on immune cell proliferation lymphocyte proliferation by MTT assay and study about the genotoxicity effect were done by ANOVA test. The cultures of human lymphocyte were treated with borax at final concentration of 0.
The value of mean absorbance reflected the anti-proliferation of lymphocyte by borax. Mean absorbance conversion can be directly related to the number of living lymphocytes. The results indicated that at the borax concentrations of 0.
The proliferation of lymphocytes was inhibited by borax.
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